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SC13 · SCIENCE THROUGH EVIDENCE

Human Anatomy and Physiology Foundations

Sixty-two original destinations implement the finite six-module anatomy/physiology foundation and whole-course synthesis. Actual CC0 tissue micrographs, original mechanism investigations and retained source-aware assessments support bounded structure–function reasoning; independent learner and practical competence remain separately assessed.

This is the course outline. Open a unit to choose a lesson; every lesson opens on its own page. Explanations and experiments live inside those lesson pages.

Preparation and course boundaries

Preparation: Cell biology, membranes and basic chemistry at General Biology I level; ratios, units and graph interpretation. No clinical training, specimen handling, programming or personal physiological measurement is required.

Course outcome: Identify tissues from actual supplied images; connect skin/bone/muscle, neural/endocrine, transport, metabolic/renal and immune/reproductive structures to bounded function; defend original integrated evidence with critique and unfamiliar transfer without clinical inference.

All lessons are directly accessible. Reused foundation explanations are identified where relevant; completing a different course does not award this course's evidence. The 62 registered lessons keep separate predictions, captures, practice responses and reflections.

Module 1 — Tissue evidence, organization and internal boundaries8 lessons

Use subject-relative directions and actual licensed tissue images; distinguish structure from function, conserve particles/water and explain feedback and shared-system coupling.

Read epithelial architecture before measuring thickness

Inspect the real epithelial image and retain two visible features and one uncertain feature. Compare model angles 0° and 60° without changing thickness. Explain why nuclear rows and apparent width cannot alone distinguish simple from stratified tissue.

Trace one flux through multiple tissue barriers

Hold epithelial resistance at 2 and vary the support resistance. Retain flux and both drops; identify a separate measurement that could distinguish a support-layer change from an altered reservoir gradient.

Conserve water and particles across a cellular boundary

Compare initial shifts −0.5,0,+0.5 L at the same outside addition 300 mosmol. Retain initial concentrations, direction and final volumes. Identify which omitted pressure or permeability assumption would invalidate the calculation.

Module 2 — Integument, skeleton and muscle11 lessons

Identify support/motion structures and explain their renewal, material geometry, joint kinematics, sarcomere activation and force boundaries without clinical or injury-threshold claims.

Locate skeletal landmarks before assigning an action

Compare radius versus humerus on the same side, then switch subject side. Separately compare sternum and vertebral column and state their anterior/posterior relationship rather than reading depth from screen left/right.

Module 3 — Neural and endocrine regulation10 lessons

Identify neural and endocrine pathways, distinguish electrical/chemical signal mechanisms, and discriminate competing transport, receptor and feedback explanations with bounded original evidence.

Module 4 — Circulation, respiration and transport10 lessons

Trace circulation and respiratory pathways, apply pressure-flow and gas-content conservation, and defend an integrated oxygen-delivery case without clinical or safety claims.

Distinguish arterial storage from mean perfusion

Compare all compliances at period 1, then change period at fixed compliance. Retain peak, trough, mean and integrated outflow, distinguishing the instantaneous pulse from the displayed runoff segment.

Resolve gas diffusion across connected barriers

Compare area and thickness changes separately. Retain both resistances and drops, then name an independent ventilation or perfusion observation needed before interpreting whole-system transport.

Conserve oxygen through unequal parallel lung pathways

Vary f at fixed bypass, then bypass at fixed f. Keep all three flow fractions, amount rates and the final denominator; explain why increasing one branch’s ventilation cannot be modeled simply by averaging pressures.

Infer flow only from a complete oxygen balance

Compare denominator changes with numerator changes. Derive the two extrema explicitly, retain units and identify a storage or sampling observation that would invalidate the steady inference.

Module 5 — Digestion, metabolism, renal and fluid regulation11 lessons

Trace nutrient transformations and renal transport, conserve energy/solute/water ledgers, and distinguish compensation of a sensed ratio from restoration of original amounts and mechanisms.

Separate preserving a medullary gradient from generating it

Reconstruct every signed local transfer and the net carrier/environment balance. Compare deep-turn concentration with final return concentration, then name the loop transport and water mechanisms intentionally missing from this exchanger.

Module 6 — Immunity, reproduction and integrated homeostasis10 lessons

Trace immune and reproductive structures, distinguish conditional defense and developmental mechanisms, and defend integrated compensation with conserved amounts and explicit capacity limits.

Full-course anatomical evidence and mechanism defense2 lessons

Connect six anatomical capability clusters through actual licensed tissue evidence, original compartment and mechanism analysis, retained first reasoning, human critique and unfamiliar transfer without clinical overclaiming.

Discriminate mechanisms and defend the full anatomical evidence portfolio

Retain the complete candidate-prediction table before selecting one. Hide and reveal the hormone and temporal records independently. Explain how uncertainty or an omitted mechanism could defeat a unique selection, then connect the logic to a named anatomical pathway without diagnosing a person.

Investigation portfolio

Keep predictions before comparison, complete raw records and units, explain competing models and test a changed case. Supplied and simulated data are labeled in each lesson. A saved notebook is not proof of experimental technique or correct reasoning.

Actual image and anatomical-coordinate evidence audit

Evidence to retain: Retain subject-relative coordinate statements, two visible features and one unresolved feature for each actual licensed image, source/assistance exposure, and separate original geometry/area-weighting calculations.

Boundary: Actual published images are guided, source-labeled evidence, not collected specimens or blinded practical validation. Model measurements are not extracted from their pixels.

Feedback and organ-system coupling

Evidence to retain: Derive residual equilibrium and alternating response, then conserve network pressure/flow while changing one branch; specify an independent observation that could reject the explanation.

Boundary: No-delay controller and fixed-resistance network omit active physiological regulation; no personal experiments or clinical inference.

Integument and bone material histories

Evidence to retain: Retain skin-layer identities, thermal boundary drops, simultaneous renewal transfers, fixed-area geometric rigidity and lagged remodeling inventory; distinguish state from flux and geometry from material properties.

Boundary: Original models and schematics, not actual skin tests, bone density measurements, injury limits or treatments.

Anatomical map, joint and sarcomere geometry

Evidence to retain: Identify subject-relative landmark regions, reconstruct link endpoints, and preserve thick/thin filament lengths while calculating changing band overlap. Compare a new orientation with a new internal geometry.

Boundary: Sparse original diagrams, not a complete atlas or independently assessed specimen practical; no physical range-of-motion challenge.

Muscle activation and mechanical boundary comparison

Evidence to retain: Separate stage delays, recruitment/frequency, active/passive force and tendon/fiber projections; close torque/local work and specify missing joint-reaction evidence.

Boundary: Fictional numerical responses, no electrical stimulation, clinical latency interpretation, exercise prescription or safe-loading assessment.

Neural structure, passive spread and regenerated signal

Evidence to retain: Identify CNS/PNS branch boundaries, reconstruct distinct ion currents at zero total current, and contrast passive attenuation with conditional regeneration; retain a branch cut versus a propagation failure prediction.

Boundary: Original circuit/ion models, not actual electrophysiology, stimulation or clinical localization; actual neuron image remains source-labeled M1 evidence.

Synaptic, sensory and branch-specific discrimination

Evidence to retain: Separate current from depolarization, contrast from absolute intensity, and shared afferent from branch-specific delay; identify an omitted dynamic or anatomical observation.

Boundary: Fictional response laws and paths; no sensory challenge, reflex measurement, drug administration or personal latency inference.

Endocrine binding, turnover and feedback identifiability

Evidence to retain: Conserve free/bound amounts, separate clearance from inverse-time rate, derive a feedback fixed point and compare endpoint-equivalent candidates using a supplied independent transient.

Boundary: Original dimensionless or arbitrary-unit models, not clinical assays, hormone interventions, diagnoses or treatment advice.

Pump, arterial storage and tissue-fluid conservation

Evidence to retain: Trace serial circuits and valve gradients, reconstruct a pressure-volume loop, close a periodic reservoir volume balance and separate barrier flow from lymph return and tissue inventory.

Boundary: Original topology and prescribed models, not actual pressure traces, clinical measurements, edema diagnoses or safe-load estimates.

Ventilation, diffusion and regional oxygen mixing

Evidence to retain: Separate total and fresh alveolar ventilation, close serial pressure drops and perfusion-weighted content mixing with explicit bypass fraction and complete denominators.

Boundary: Fictional volumes/resistances/contents; no personal respiratory challenge, measured diffusion capacity or gas-treatment recommendation.

Carried oxygen, inverse flow and integrated feasibility

Evidence to retain: Distinguish saturation/capacity/content, derive deterministic inverse-flow bounds and reject a demand exceeding a supplied extraction boundary without inventing a valid steady state.

Boundary: No real blood samples, individual cardiac-output inference, clinical extraction threshold or activity prescription.

Digestive transformation, routes and energy composition

Evidence to retain: Trace digestive organs and separate hydrolysis atoms, finite absorptive supply, portal/lymph material routes and energy versus stored-mass composition.

Boundary: Original generic chains, transport coefficients and storage units; no actual meal assay, feeding recommendation or body-weight prediction.

Nephron pathway and solute-clearance discrimination

Evidence to retain: Identify glomerular/tubular/vascular routes, conserve filtered/returned/secreted amounts, retain threshold equality, distinguish clearance from urine water and account for signed exchanger transfers.

Boundary: Virtual generic solute and maintained gradient; no personal urine collection, diagnostic threshold or claim that an exchanger generates the renal gradient.

Water, buffer and concentration compensation

Evidence to retain: Close water/osmole ledgers, compare buffer endpoint ratios with missing amounts, and demonstrate concentration restoration without complete amount/volume restoration.

Boundary: Supplied final pools and arbitrary units; no real physiological challenge, clinical pH interpretation or fluid prescription.

Conditional defense, recruitment and recognition

Evidence to retain: Keep stage denominators, input/removal timing, precursor/delay contrasts and clone-specific signal shares. Predict before changing one boundary and identify an alternative mechanism.

Boundary: Inert tokens and original numerical responses, not actual agents, cultures, diagnostic assays or protective efficacy.

Reproductive anatomy, nuclear products and developmental exchange

Evidence to retain: Annotate named pathways, retain nuclear versus functional products, distinguish level/duration feedback, conserve cellular volume and close separate maternal/fetal tracer streams.

Boundary: Original virtual records, not reproductive specimens, fertility timing, embryo culture or fetal exposure estimates.

Whole-course compartment and mechanism defense

Evidence to retain: Retain local uptake limits, complete flow-weighted return, separate marker currency and all compatible endocrine candidates. Add the actual licensed tissue-image audit and a six-module action table with new first responses and source identity.

Boundary: Actual source-labeled tissue images are distinct from invented physiology. No individual diagnosis, participant challenge, clinical procedure or fabricated independent practical competence.

Mixed assessment and cumulative project

Open the retained response and project workspaces. Practice, saved work and independently reviewed proficiency remain separate.

Mixed assessment and retained reasoning

These 33 course-specific public tasks are practice, not a secure examination. Each retains up to three immutable written responses, known feedback exposure before each response, and human rubric critiques. Drafts remain editable. No text-length check or self-reported review certifies correctness, independence, laboratory skill or mastery.

1. Defend local delivery and separate renal material accounting

Use total flow 8, renal fraction 0.6, content 10, extraction ceiling 0.5, renal demand 8 and other demand 32. Calculate local flows/capacities/uptakes, unmet demand and flow-weighted venous content. Marker plasma concentration 2, filtration 0.1 of renal flow, return 0.5 and no secretion define a separate renal ledger. Compare routing 0.2 at unchanged total flow.

Course-specific review criteria

  • Flows 4.8/3.2;capacities 24/16;uptakes 8/16;unmet 16
  • Venous contents 25/3 and 5;mixture 7;total uptake 24
  • Marker filtered 0.96,returned 0.48,excreted 0.48 in distinct units
  • At 0.2 both demands met,total uptake 40,mixedcontent 5,markerexcretion 0.16

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

2. Keep compatible mechanisms until discriminating evidence arrives

For candidates(P,k,g)=(2,1,1),(4,1,0.5),(4,2,1), steady H=P/k and response R=gH. Given R2 and H2, list survivors. Then add virtual remaining fraction exp(−2) one time unit after production ceases. Explain which assumptions make selection possible and why it is not a diagnosis.

Course-specific review criteria

  • All responses 2;hormones 2/4/2
  • Hormone 2 retains candidates 0 and 2
  • Temporal fraction selects k 2/candidate 2 within supplied models
  • Exact data,one compartment,fixed gain and candidate completeness are assumptions

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

3. Defend tissue identity and structure–function limits

Independently inspect two of the four supplied CC0 micrographs. Retain exact image identity, source/creator/reuse basis, visible positive features and one plausible alternative. Connect one feature to a bounded function, identify what magnification/preparation/sectioning can hide, and distinguish the actual image from an original model diagram. Declare prior labels and feedback exposure.

Course-specific review criteria

  • Two exact actual image/source identities and permission/provenance
  • Visible features rather than title-only identification
  • Plausible alternative and section/preparation limitation
  • Bounded structure–function inference;no diagnosis or false blinded claim

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

4. Retain the complete six-module anatomical action audit

Before feedback, construct a six-row evidence table linking actual tissue identification; skin/bone/muscle mechanics; neural/endocrine pathway perturbation; circulation/respiration transport; digestive/renal/fluid conservation; and immune/reproductive/integrated response. For every row include one original calculation or annotated anatomical argument, a changed-case response, source, assumption and observation that could reject the explanation. Link first reports rather than copying public answers.

Course-specific review criteria

  • All six specified capability clusters with substantive retained actions
  • Named structures and exact mechanism/units
  • Changed-case reasoning and competing explanation
  • Actual sources,first responses,exposure and unmet practical gates

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

5. Separate immune sequence and response timing

Begin with 10000 inert tokens, entry fraction 0.3 and conditional removal 0.5. Separately compare naive precursor 1 with an eightfold memory starting pool after 2 response steps: naive waits 2 steps, memory doubles immediately. Calculate stage inventories and endpoint clones; explain why neither remaining tokens nor clone ratio measures actual infection or protection.

Course-specific review criteria

  • Excluded 7000, removed 1500, remaining 1500
  • Naive 1, memory 32, ratio 32
  • Conditional downstream denominator and precursor/delay assumptions
  • Actual susceptibility and protection require other evidence

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

6. Distinguish a mixture from a removal mechanism

Use clone amounts A=1 and B=3 with responses A:[X4,Y1], B:[X1,Y3]. Calculate total signals and component shares. Separately a population starts 4 with recruitment 2 and removal coefficient 0.5 until time 3, then recruitment stops. Derive the post-stop half-life and population at time 6 without treating either packet as a diagnostic assay.

Course-specific review criteria

  • Signals X7,Y10; A share of X4/7 and B share of Y9/10
  • Pre-stop equilibrium4 and population4 at cessation
  • Half-life 2 ln2; final4e^(−1.5)
  • Signal specificity and input/removal mechanisms distinguished

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

7. Keep nuclear products, lineage allocation and exchange distinct

For four replicated primary cells of an original 2n=6 species completing the sperm pathway, calculate final nuclear products, chromosomes per nucleus and total DNA in C. In a separate no-growth cleavage packet use four rounds, total cellular volume64 and lineage fraction0.5. Finally use maternal/fetal tracer flows1/1 with inlet concentrations10/0 and unit outlet-difference conductance. Close all three ledgers without combining their unrelated biological units.

Course-specific review criteria

  • 16 haploid nuclei,3 chromosomes each,total16C
  • 16 cells,averagevolume4,lineages8/8,totalvolume64
  • J10/3,maternalout20/3,fetalout10/3; separate amount streams close
  • No actual developmental staging or fetal exposure inference

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

8. Separate a trigger, a compensated signal and a feasible balance

For signal sequence1,2,6,6,1 and threshold5, trigger only after two consecutive qualifying observations. Independently compare pressure P=2VR at V2/R2 with referenceV4/R1. In the thermal packet T37, environment20, metabolism60, dryloss2(T−environment), capacity40, find required/actual evaporation and initial stored heat. Explain three different meanings of an apparently successful response.

Course-specific review criteria

  • Trigger observation4, not cycle day or ovulation date
  • Pressure8 restored but volume deficit2 remains
  • Dryloss34,required and actual evaporation26,storedheat0
  • Condition satisfaction, proxy compensation and energy feasibility are distinct

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

9. Freeze an integrated mechanism-discrimination plan

Before feedback, select an unfamiliar virtual immune, reproductive or integrated regulation record. Name structures, inputs, conserved amounts and sensed variables. Propose two mechanisms compatible with an endpoint and a changed observation that discriminates them. State source identity, fictional coefficients, no-personal-testing boundary and what remains unverified.

Course-specific review criteria

  • Named anatomical pathway and original source identity
  • Distinct amounts, rates and sensed variables
  • Two plausible mechanisms and discriminating observation
  • First response, exposure and independent practical gates preserved

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

10. Close chemical digestion and finite absorptive supply separately

Three two-residue glucose chains undergo complete hydrolysis: count water, released glucose and product C/H/O. Separately surface factor3 and concentration1 with supply2C and capacity4AC/(2+C) give what uptake and outgoing amount? Name digestive organs/secretions and explain why enzyme identity, finite supply and uptake rate are different evidence.

Course-specific review criteria

  • Three waters,six glucose,C36/H72/O36
  • Supply2,capacity4,actual uptake2,remainder0
  • Correct digestive/absorptive route; bile is not a hydrolytic enzyme
  • Atom conservation distinct from amount/time and actual nutritional inference

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

11. Separate nutrient-route retention from energy composition

Soluble portal input60 with immediate liver retention0.75 and independent lymph lipid packet20: find retained/systemic amounts without converting them into calories. Separately energy input300 versus expenditure150 is routed entirely to the4-unit/mass store or entirely to the9-unit/mass store: compare masses and conserved energy. Why is this not a body-weight forecast?

Course-specific review criteria

  • Soluble retained45,systemic15; lymph lipid20 unchanged
  • Surplus150 gives mass37.5 versus50/3
  • Both retain150 energy, unlike nutrient amounts not summed as calories
  • Water, synthesis costs and adaptive physiology absent

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

12. Reconstruct a tubular amount and a clearance comparison

Filtration3 at plasma concentration4, reabsorption fraction0.75 and secretion2: find excretion. In a separate generic-solute packet filtration2,C3,Tm6, what is spill? In the clearance packet plasma2,filtration3,net tubular flux−3 and urine flow0.5: find excretion, urine concentration and clearance. Explain why final concentration alone does not identify filtration.

Course-specific review criteria

  • Filtered12,returned9,secreted2,excreted5
  • Threshold equality gives spill0
  • Excretion3,urine concentration6,clearance1.5 versus inert marker3
  • Separate packet assumptions and units; no real diagnostic inference

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

13. Keep countercurrent transfer distinct from collecting-duct water return

Carrier startsC2 and follows maintained4,8,4,2 with fractional approach0.5 and flow1: reconstruct concentrations and signed transfers. Separately delivered water6,return fraction0.25 and osmole output6 give what urine water/concentration? Explain multiplier versus exchanger and ADH permeability versus a gradient.

Course-specific review criteria

  • Concentrations3,5.5,4.75,3.375; transfers1,2.5,−0.75,−1.375,total1.375
  • Water return1.5,urine4.5,concentration4/3
  • Gradient is supplied; loop transport/water selectivity differ from vascular preservation
  • ADH changes permeability conditionally, not solute creation or a direct fixed urine concentration

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

14. Retain a plan that distinguishes ratio compensation from full recovery

The generic buffer reference is base8/acid2,pKa6. Endpoint base4/acid1 has what pH and missing pools? A separate solute8/water4 compartment adds solute4 and water2: what concentration and volume remain? Before feedback, retain an original plan distinguishing normalized concentration/pH from restored amounts, with competing endocrine/renal mechanisms and an independent observation.

Course-specific review criteria

  • Same pH6+log10(4),but base lower4 and acid lower1
  • Final solute12,water6,concentration2; excess amount4 and water2
  • Original first plan with independent amount/volume or flux evidence
  • No diagnosis from endpoint, retained assistance/exposure and unfamiliar review

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

15. Connect valve gradients, loop work and arterial storage

Trace systemic veins through the right heart, lungs and left heart back to systemic arteries. With atrial pressure2, ventricular6 and arterial8, identify both ideal valve states. For a separate loop EDV80/ESV40 mL, filling1/ejection6 kPa, calculate stroke, fraction and net work. For reservoir C1,R2,pulse6,T2, find pressure jump, mean flow/pressure and integrated period outflow.

Course-specific review criteria

  • Correct chamber/valve/circuit sequence; both snapshot valves not-open
  • Stroke40 mL,fraction0.5,net work0.20 J
  • Jump6,mean flow3,mean pressure6,outflow6
  • Snapshot, prescribed cycle and periodic reservoir are different conditional models

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

16. Keep fluid inventory distinct from gas diffusion

In the fluid packet Pc16,interstitial2,colloid6,K0.5,lymph0 and initial tissue20: find outward flow, tissue after2 and opposite vascular change. Separately gas thickness3/area2 with total partial-pressure difference12 gives what serial resistances, flux and drops? State why water inventory and gas diffusion cannot be substituted for one another.

Course-specific review criteria

  • Fluid flow4,tissue28,vascular change−8
  • Gas resistances3/1,flux3,drops9/3
  • Different conserved quantities, driving terms and fixed assumptions
  • No universal venous-reabsorption or clinical fluid inference

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

17. Audit equal moved air with unequal downstream transport

Compare tidal/frequency pairs0.2 L×30/min and0.6 L×10/min with fixed dead space0.15 L. Then use total flow4, bypass0.5 at content6, and f0.25 of nonbypass flow through content18 versus the rest at10. Find ventilation partitions and all branch amount rates/mixed content. Why does equal minute ventilation not determine the mixed content?

Course-specific review criteria

  • Both minute6; fresh alveolar1.5 versus4.5 L/min
  • Flows0.5/1.5/2 and amount rates9/15/12
  • Mixed36/4=9
  • Ventilation and supplied perfusion/content evidence are separate, not a calibrated causal prediction

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

18. Separate saturation, inverse flow and an unmet demand

Use p1/capacity20 with S=p²/(1+p²), dissolved0.2p. Separately arterial content10, uptake6 and venous8 with uptake±1 and venous±0.5: find central flow/bounds. Finally at flow4,content10,maximum extraction0.6 and demand30, find delivery, maximum uptake, unmet demand and boundary venous content. What extra measurements distinguish poor ventilation, low capacity and low flow?

Course-specific review criteria

  • S0.5,bound10,total10.2
  • Flow3,allowed bounds2 to14/3
  • Delivery40,limit24,unmet6,boundary venous4; requested demand infeasible
  • Independent gas, capacity, content and flow evidence, not diagnosis from one output

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

19. Retain an original integrated transport discrimination plan

Before feedback, choose a supplied oxygen-delivery change. Trace its anatomical route and propose at least two mechanisms at different stages, such as ventilation partition, regional mixing, binding capacity or flow. Predict a discriminating independent observation, close one amount/volume/work ledger, and identify a failed feasibility assumption. Retain source, assistance and prior answer exposure.

Course-specific review criteria

  • Correct connected anatomical pathway and distinct mechanisms
  • Independent discriminator rather than restating the same endpoint
  • Complete units, denominator and conservation/feasibility checks
  • Original first plan and unfamiliar reviewer transfer; no real physiological challenge

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

20. Distinguish a disconnected branch from opposing currents

The R→S→M and S→B circuit receives input 1 but S→M is absent. Identify spinal, motor and ascending outputs and CNS/PNS boundaries. Separately EA=−60, EB=60 and both conductances are 1: derive steady voltage and both outward currents. Why does zero net current not mean no ion movement?

Course-specific review criteria

  • Spinal 1, motor 0, ascending 1; abstract branch roles distinguished from actual lesion localization
  • V=0; A current +60 and B current −60
  • Zero sum is not separate electrochemical equilibrium or proof of unchanging reservoirs

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

21. Separate a local attenuation failure from a shunted voltage

Initial amplitude 10, λ1 and node spacing1, threshold4: find first-node arrival and fourth-node output; compare passive amplitude at distance4. Separately leak1, excitatory conductance1 and shunt2 with reversals −60/0/−60: find voltage and excitatory inward current, comparing shunt0. Explain why a larger inward current can coexist with smaller depolarization.

Course-specific review criteria

  • Arrival 10/e≈3.679 below threshold; regenerated output0; passive10e^−4≈0.18316 remains nonzero
  • With shunt: V−45, inward45, depolarization15; without: V−30,current30,depolarization30
  • Greater total conductance and driving force, not an assumed spike waveform

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

22. Recognize unchanged contrast and shared timing components

Compare center/surround 8/4 with10/6 under R=C−S and baseline20. Then use afferent0.2 m at40 m/s, somatic additional12 ms, autonomic additional13 ms plus postganglionic0.1 m at2 m/s. Find both total delays and their difference. Which change preserves contrast, and which shared path change preserves the delay difference?

Course-specific review criteria

  • Both contrast4 and output24
  • Afferent5 ms, somatic17 ms, autonomic68 ms, difference51 ms
  • Uniform intensity shifts preserve contrast; shared afferent changes shift both times equally

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

23. Keep binding, amount and turnover parameters distinct

Total hormone4 with carrier capacity0: find free concentration and receptor occupancy using Kd1. Separately secretion6, clearance2 and volume3 from C0=0: find steady concentration, steady amount, time constant and initial slope. Compare a virtual steady C3 at volume2 with candidate clearance1 versus3; fit secretion and predict post-input concentration at time1.

Course-specific review criteria

  • Free4, occupancy4/5; carrier absence does not make occupancy1
  • Steady C3, amount9, time constant1.5, initial slope2
  • Secretion3 versus9, post-input concentrations3e^−0.5 versus3e^−1.5
  • Virtual independently supplied transient, not a real hormone test

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

24. Retain a discriminating regulation plan and fixed-point check

For Pnext=.8P+.2a/(1+H), Hnext=.8H+.2bP, use drive4 and target gain0.5. Derive the positive fixed point. Before feedback, retain an original plan distinguishing altered target sensitivity from altered upstream drive or clearance, using at least one independent supplied observation. Identify neural/endocrine structures, controlled assumptions, competing predictions and prior assistance.

Course-specific review criteria

  • H*=1, P*=2; H²+H=ab=2
  • Original first plan with two distinct mechanisms and an independent observation
  • Correct structure and feedback direction, uncertainty and nonclinical boundaries
  • Retained source/feedback exposure and reviewer-assigned unfamiliar transfer

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

25. Separate a surface boundary from a delayed tissue history

Thermal reservoirs 30/10, external resistance4, subcutaneous1, dermal2 and epidermal1: find flow and surface temperature. Separately three renewal stages start20 each, input5 and transfer0.5: find first two state vectors and steady per-stage inventory. Explain why a stable surface observation does not identify basal activity.

Course-specific review criteria

  • Total resistance8, flow2.5, surface20
  • States15/20/20 then12.5/17.5/20; equilibrium10 per stage
  • External boundary versus internal transit mechanisms and unmeasured processes distinguished

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

26. Audit equal material with unequal geometry or timing

An annulus has inner radius2 and fixed material areaπ with E2: find outer radius, I, EI and rigidity ratio to a same-area solid at E2. Separately a 100-unit remodeling packet resorbs3 per step for five steps then forms6 per step for five: find minimum and final inventory. Why is neither result a fracture prediction?

Course-specific review criteria

  • R√5, I9π/4, EI9π/2, ratio9
  • Minimum85, final115
  • Geometry, material quality, timing and actual failure evidence remain distinct

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

27. Keep anatomical identity and model geometry separate

Identify a subject-left lateral forearm bone and its front-view screen side. For links3/2 with α0° and additional bend120°, calculate endpoint and distance. Separately sarcomere L3.2, thin0.8 and thick1.6: calculate A, total I, H and overlap. Explain why the sparse diagrams do not certify practical identification.

Course-specific review criteria

  • Radius; viewer-right
  • Endpoint(2,√3), distance√7
  • A1.6,I1.6,H1.6,overlap0; no filament shortening
  • Source/model familiarity and independent unfamiliar practical evidence distinguished

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

28. Separate electrical, active, passive and leverage quantities

Axon path 0.6 m, speed 60 m/s plus delays1,3,6 ms: total delay? Four units with maxima1,2,3,4 at40 Hz and factor f/(f+20): force? At L1.4,u0.25 use the supplied active/passive curves. For torque12, radius0.04, tendon90° and pennation60°, find tendon/fiber forces. State why no single result identifies clinical function or a safe load.

Course-specific review criteria

  • Propagation10 ms,total20
  • Recruitment force20/3
  • Active9,passive32,total41
  • Tendon300 N,fiber600 N; stages and force projections distinguished

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

29. Retain an independent support-and-motion explanation plan

Before feedback, choose a supplied integumentary or musculoskeletal change. Name the structures and subject-relative orientation, identify at least two competing material/activation/boundary mechanisms, predict a discriminating observation and specify conserved quantities. State which evidence is a labeled schematic or invented packet and what unfamiliar image/model task a reviewer should provide. Retain assistance and prior exposure.

Course-specific review criteria

  • Correct anatomical structures and reference frame
  • Two mechanistically distinct predictions, not renamed versions of one calculation
  • Material, timing and mechanical boundary records
  • No clinical/safe-loading conclusion; retained first plan and unfamiliar review

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

30. Retain actual tissue observations before source feedback

Use the four downloaded CC0 tissue images and their provenance manifest. Before opening source interpretations, record two visible features, a tentative major tissue class and one unresolved feature per image; retain any label/alt-text exposure honestly. Explain why striations alone do not separate skeletal and cardiac muscle, why nuclear rows do not alone count epithelial layers, and why one neural process cannot always be assigned from a single field. Give source identity, reuse basis and a proposed genuinely unfamiliar reviewer-assigned image task.

Course-specific review criteria

  • Actual image identity and license/provenance retained
  • Eight concrete visible observations and four uncertainties, not invented measurements
  • Feature combinations, tissue-function reasoning and explicit source/alt-label exposure
  • Separate guided recognition from independent practical evidence

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

31. Separate orientation and sampling from tissue change

A landmark has patient-left x−1 and superior z2. Give front-view screen horizontal coordinate and a plane fixing z. A 30 μm slab is crossed at 60° from its normal. Separately fields of areas 30/70 have target fractions 0.8/0.2. Calculate path length, total area fraction and equal-field mean, stating why neither observed width nor field fraction establishes whole-organ change.

Course-specific review criteria

  • Subject-right landmark displays screen −1; transverse plane fixes z
  • Oblique path 60 μm
  • Weighted fraction 0.38 versus equal-field 0.5; different denominators

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

32. Keep a resistance ledger separate from an osmotic ledger

Passive layers R1=1,R2=4 share total concentration difference 10. Find flux and drops. Separately the fictional 5 L compartment system receives 150 mosmol outside with no initial shift: outside particles 750, inside 900. Find final concentration, final volumes and water shift. Explain why these calculations do not estimate absorption or prescribe fluids.

Course-specific review criteria

  • Flux 2, drops 2/8
  • Common concentration 330, outside 25/11 L, inside 30/11 L
  • Outward water 3/11 L; explicit passive/impermeant/no-pressure boundaries

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

33. Explain a stable error and a coupled unchanged branch

A controller starts x4 with gain1.5 and disturbance1: find equilibrium and next two states. Separately supply difference12, shared resistance2 and parallel RA1/RB4: find branch pressure, total flow and both branch flows. What independent observations distinguish target shift from disturbance, or altered branch resistance from shared supply change?

Course-specific review criteria

  • Equilibrium 2/3, next −1 then 1.5
  • Parallel resistance 0.8; total 30/7, branch pressure 24/7
  • A24/7 and B6/7; independent target, actuator and pressure evidence

Include calculations with units, source or dataset provenance, assumptions, competing explanations and limitations as relevant. The draft is saved but is not a locked response until submitted.

0/3 responses retained. No recorded feedback exposure for this task version. Earlier versions may already be familiar. Public inspectability still prevents certification of unfamiliarity.

Retain a criterion-by-criterion human review

Reviewer identity and role are declarations, not authenticated credentials. Unsaved review fields below are lost on navigation. Review every criterion with an exact quotation, calculation or evidence citation and a next step.

Whole-course structure, mechanism and integrated-homeostasis portfolio

Build an original six-module anatomical portfolio using the four actual licensed tissue micrographs and distinct virtual mechanism records. Retain complete first reasoning and source identities; do not relabel model outputs as participant observations, guided image recognition as blinded performance or a course checklist as clinical competence.

  1. Freeze source and six-module investigation plan

    Before public feedback, identify actual image sources, fictional mechanism packets, all six capability rows, competing explanations and the evidence needed to discriminate them. Preserve assistance and prior exposure.

    Evidence to retain: First plan with source/version/reuse basis, original predictions and explicit no-participant-testing boundary.

  2. Defend actual tissue observations and mechanics

    Audit at least two actual supplied micrographs with visible features and alternatives, then connect skin/bone/muscle organization to a retained lever, contraction or structural calculation and changed case.

    Evidence to retain: Exact image identity, observations, anatomical annotations, mechanical units and no diagnostic/injury claim.

  3. Connect regulatory pathways and transport

    Trace a named neural/endocrine pathway and perturbation, defend response timing and receptor alternatives, then close a circulation/respiration flow or diffusion budget and integrated regional delivery case.

    Evidence to retain: Named pathway, compatible mechanisms, units, capacity limits and flow-weighted transport calculation.

  4. Close metabolic, renal and response boundaries

    Retain a digestive/energy ledger and renal/fluid amount balance distinguishing compensation from restoration. Add immune and reproductive mechanism explanations and a changed integrated response; never combine unlike material currencies.

    Evidence to retain: Conserved amounts, conditional denominators, named structures, developmental/immune limits and nonclinical conclusions.

  5. Freeze full first report and obtain substantive critique

    Submit all six rows, actual image audit, cumulative cases, uncertainty and rejected alternatives. Obtain criterion-linked human review; preserve the original report even when a correction is required.

    Evidence to retain: Immutable first report, source/action crosswalk, reviewer rationale and practical/independence limitations.

  6. Revise and demonstrate unfamiliar transfer

    Retain a justified revision, then receive a genuinely new reviewer-assigned anatomical image or mechanism packet before writing a fresh response. Declare assistance/exposure and provide supervised practical evidence only if separately claimed.

    Evidence to retain: Original and revised reports, critique, unfamiliar assignment and first response; unmet independent practical gates remain visible.

Project review criteria

  • Actual tissue provenance and visible features
  • Structure–function and mechanics
  • Neural/endocrine pathway alternatives
  • Transport and compartment conservation
  • Metabolic/renal/immune/reproductive boundaries
  • Complete original six-module reasoning
  • Substantive critique,revision,unfamiliar transfer and practical limits

Retain raw-data identifiers, provenance, units, prior predictions, methods, calculations, competing explanations and safety boundaries. State explicitly when data are simulated, supplied or genuinely observed. This saved text cannot verify a real experiment; do not invent measurements or completed supervised work. Maximum 12,000 characters; retain larger evidence files separately and cite them.

A nonempty report is only a saved submission. First and revised reports remain separate and cannot be overwritten. A critique of the first report is required before retaining one revision.

Fresh transfer direction

A reviewer supplies a new tissue field, changes a force/flow boundary, alters receptor versus clearance evidence or removes an assumed feedback relation. Explain what survives, what changes and what remains unresolved without individual clinical inference.

A human must supply the actual new task, evidence and conditions before the learner responds. The transfer-direction text is not itself an unseen assessment. Use the retained assignment form after the first project; exposed public task identifier: expanded-public:college-anatomy.

Science backups preserve each course's separate responses, exposure, rubric reviews and project history. Older backups do not reset attempts or erase known exposure. Divergent same-version immutable responses and incompatible same-version project histories are rejected rather than silently replaced; preserve both files for review.

Sources and boundaries
  • All 62 finite destinations authored and independently source/action reviewed; this does not certify learner performance, supervised practical competence, institutional equivalence or professional authorization.
  • One-semester foundations, not an equivalent two-semester professional anatomy/physiology laboratory sequence.
  • Actual CC0 images provide guided observation; independent identification and any required supervised specimen practical remain unverified learner gates.
  • No patient information, physical examination, physiological challenge, diagnosis, treatment or microorganism handling is requested.

Original LearnAI explanations and tasks use the references for scientific scope. Any attributed dataset or image has its own declared provenance. Laboratory or field activity requires an appropriate educator-approved protocol; no hazardous real-world operation is required by the guided path.

Save a science backup or import one

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