Separate recruitment, persistence and resolution
Inflammation coordinates vascular changes, signaling and cellular recruitment in response to infection or damage. Increased permeability and recruited cells can support defense and repair, but an excessive or persistent response can also contribute to tissue injury. Protective function and harmful consequences are therefore not a single quantity that increases monotonically with every response marker.
Learning outcome: Reconstruct each old-stock removal and new arrival. Compare equal endpoint stock with unequal throughput, then explain why the cumulative stock alone cannot establish protection or injury.
Starting recap
Connect host defenses and adaptive mechanisms to bounded fictional evidence while separating detection, conditional probabilities, timing and causal claims.
All lessons are open directly. Your saved experiments remain when you leave and return.
Try
At recruitment 4 and resolution fraction 0.5, starting stock 8 stays 8 because four units leave and four enter each step. Four steps recruit 16 and resolve 16. At recruitment 2 with the same resolution, stocks become 6,5,4.5,4.25; total resolved is 8+8−4.25=11.75.
Open the experimentPredict
Can the same final response stock hide substantial recruitment and resolution?
Experiment
Reconstruct each old-stock removal and new arrival. Compare equal endpoint stock with unequal throughput, then explain why the cumulative stock alone cannot establish protection or injury.
Keep recruitment and resolution in a simultaneous stock ledger
Worked teaching model · synthetic values · Original R0=8 and simultaneous R_next=(1−b)R+a, four steps. Removal uses old stock, not newly recruited stock. Weighted cumulative burden is a stipulated model output, not measured harm or clinical response.
Reset keeps your prediction, captures and practice history.
Recruitment and resolution must use the declared timing rule; stock is not itself a measured damage score.
Original R0=8 and simultaneous R_next=(1−b)R+a, four steps. Removal uses old stock, not newly recruited stock. Weighted cumulative burden is a stipulated model output, not measured harm or clinical response.
| Arbitrary time | Original response units |
|---|---|
| 0 | 8 |
| 1 | 8 |
| 2 | 8 |
| 3 | 8 |
| 4 | 8 |
| Quantity | Value | Unit |
|---|---|---|
| Response stock after four steps | 8 | units |
| Sum of old stocks over four intervals | 32 | unit intervals |
| Total recruited | 16 | units |
| Total resolved | 16 | units |
| Formal steady stock | 8 | units |
Supplied fictional records only. No participant testing, pathogen exposure, diagnosis, treatment or personal medical inference is requested.
Recruitment and resolution must use the declared timing rule; stock is not itself a measured damage score.
Original R0=8 and simultaneous R_next=(1−b)R+a, four steps. Removal uses old stock, not newly recruited stock. Weighted cumulative burden is a stipulated model output, not measured harm or clinical response.
Captures preserve recipes and replay their calculated results. They are synthetic model evidence, not physical measurements.
Understand
Apply
Public practice checks a specific claim. It does not establish independent mastery.
Use recruitment 6 and resolution fraction 0.75. Find the first two stocks and the formal steady stock.
Continue
Completion requires a saved prediction, at least one capture and a reflection. Presence checks do not grade your reasoning.
Skipping retains experiments and awards no mastery.
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